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Failure To Reproduce Scientific Results

With the release of Zyprexa, a second-generation antipsychotic, Eli Lilly was certain it had hit pay dirt. The second-generation antipsychotics, known as the atypical antipsychotics, or atypicals, had an improved side effect profile over the older antipsychotics, and the original research on large numbers of schizophrenics in the 1990s showed great improvement for patients treated with […]

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The Bipolar Road Less Traveled: Beyond Lithium, Part II

Who didn’t read “The Road Not Taken” by Robert Frost in some high school English class? Perhaps you aren’t all privy, as I am as an undergraduate English major, to certain fascinating facts about it– Frost said of his own poem, “it’s a tricky poem – very tricky!” Each stanza follows an a b a […]

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The Bipolar Road Less Traveled: Beyond Lithium, Part I

Once upon a time, if you were diagnosed with bipolar disorder, you were treated with lithium. And, once upon a time, it worked. According to the Report of the Surgeon General, “Success rates of 80 to 90 percent were once expected with lithium for the acute phase treatment of mania (e.g., Schou, 1989); however, lithium […]

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Knitting up “the raveled sleave of care”: Sleep and Bipolar Disorder

Sleep. I, for one, am a huge fan. I love that feeling of drifting off, right before my consciousness checks out, and I adore that well-rested feeling I have when I first open my eyes after a productively-slept night. [Those nights are becoming fewer and farther between as I age, but that’s just another one […]

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